Concomitant Crohn’s Disease and Anti-Glutamic Acid Decarboxylase (GAD)-Associated Autoimmune Encephalitis: A Case Report
نویسندگان
چکیده
Crohn's disease is an inflammatory, autoimmune disorder that predominantly affects the intestines but can also affect extraintestinal organs. Certain neurological conditions, such as encephalitis, develop along with this disease. In case report, we present a of anti-glutamic acid decarboxylase (GAD) antibody-associated encephalitis occurred shortly after diagnosis and was unrelated to treatment nutritional deficiencies. After significant weight loss (24 kg) persistent diarrhea, patient diagnosed by colonoscopy biopsy. Within two weeks diagnosis, he experienced altered consciousness memory impairment, followed rapid deterioration in respiratory distress, leading intubation admission intensive care unit. His brain MRI revealed asymmetrical diffuse cortical diffusion restrictions, hyperintense signals on fluid-attenuated inversion recovery (FLAIR) sequences, pachymeningeal contrast enhancement involving both cingulate gyri, bilateral insular cortices, amygdalae, hippocampi, right precuneus. Analysis cerebrospinal fluid (CSF) slight elevation CSF proteins, tested positive for serum anti-GAD antibodies. The responded favorably seven-day course intravenous methylprednisolone, five days immunoglobulin (IVIG), oral corticosteroids. Subsequent consisted monthly IVIG, azathioprine, vedolizumab, resulting no neurologic sequelae except mild amnesia. A follow-up at three months showed nearly complete disappearance lesions. This first reported anti-GAD-associated occurring presence
منابع مشابه
Cerebellar ataxia associated with anti-glutamic acid decarboxylase (anti-GAD) autoantibodies: a rare and puzzling disease.
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CASE A 51 year-old man presented to our hospital with nine-years history of progressive gait instability, difficulty walking and insulin dependent diabetes. Family history was unremarkable. On examination, there was ataxic gait, severe limb and trunk ataxia, and dysarthria. He scored 65 in International Cooperative Ataxia Rating Scale (ICARS) and 20 in Scale for Assessment and Rating of Ataxia ...
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ژورنال
عنوان ژورنال: Cureus
سال: 2023
ISSN: ['2168-8184']
DOI: https://doi.org/10.7759/cureus.45344